| 세션명 | 대학원생 구두발표(코스맥스) |
|---|---|
| 발표장 | 제6회장 |
| 논문코드 | OC-6 |
| 발표일 | 2024-04-3 |
| 발표시간 | 16:30-16:45 |
| 논문제목 | Nitric oxide-scavenging hyaluronic acid nanoparticles for osteoarthritis treatment |
| 발표자 | 나윤영 |
| 발표자 소속 | 포스텍 |
| 저자 | 나윤영, 김원종† |
| 소속 | 포스텍 |
| 논문초록 | Osteoarthritis(OA) is marked by inflammation, pain, and cartilage degradation, with elevated nitric oxide(NO) levels implicated in OA-related inflammation. We introduce a novel approach using a NO-scavenging hyaluronic acid conjugate(HA-NSc) with lubricating and anti-inflammatory properties for OA treatment. A derivative of o-phenylenediamine with NO-scavenging capability(NSc) was synthesized and chemically conjugated to HA. HA-NSc conjugate formed self-assembled nanoparticles(HA-NSc NPs) under aqueous conditions due to its amphiphilicity. HA-NSc NPs reduced NO levels and inflammatory cytokines under the activated murine macrophage model. In an OA animal model, HA-NSc NPs alleviated pain and reduced cartilage damage, demonstrating dual therapeutic action by combining HA’s lubricating property with NSc’s NO-scavenging ability. These results highlight HA-NSc NPs as promising agents for OA treatment, addressing pain, inflammation, and joint damage, suggesting their potential for OA therapy. |
THE POLYMER SOCIETY OF KOREA